Perfluoroalkyl substances (PFASs) are ubiquitous in the environment today and they have been detected even in remote areas such as the Arctic. PFASs can be transported by the atmosphere and ocean currents but the transport mechanism is not fully understood. PFASs may be harmful to organisms due to their persistence in the environment, bio-accumulation potential and toxicity. Studies have shown that PFASs can cause adverse effects on the metabolism as well as the endocrine- and reproduction systems in organisms. In this study, PFASs were investigated in glaucous gull (Larus hyperboreus) (n=5) and black guillemot (Cepphus grylle) (n=4) from Svalbard.

Inclusion body disease (IBD) affecting boas and pythons is a serious and common disease. Boas can be clinically healthy carriers, which makes control of the disease difficult. The causative agent has not yet been confidently identified, and therefore there are no serodiagnostic tests available. Today, histopathologic examination of tissue biopsies is the recommended antemortem diagnostic method, but there are several disadvantages. The objective of this study was to compare the sensitivity of two diagnostic methods ? liver biopsies and blood smears, and to evaluate ultrasoundguided needle biopsy of the liver.

Aquatic organisms are usually not exposed to single substances but rather to mixtures of toxicants in streams located in agricultural areas. The transport of pesticides used in the agricultural area in Sweden is monitored with continuous environmental supervision every year. During 2002-2008 an average of 10 pesticides were found in each sample and 40% of the samples contained substances with concentrations higher than the Water Quality Standards. Chemical risk management is normally based on single-test evaluations. A problem when assessing mixture toxicities is that the constituents and concentrations of pollutants in the environment vary greatly.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: BCAA supplementation in patients undergoing resection for liver cancerAuthor: Mikael Semaan and Viktor SjölingSupervisor: Fredrik BertzExaminer: Frode SlindeProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: April 10, 2013BackgroundLiver cancer is the fifth most common cancer worldwide and the third largest to cause death. Protein-energy malnutrition is common in patients with liver disease and they often suffer from changes in the hepatic metabolism of nutrients and other substances. There is a basis for recommending BCAA supplementation in other certain liver diseases. Given the similar clinical picture of liver cancer surgery, it is possible that supplementation of BCAA can be beneficial for these patients as well.ObjectiveThe aim was to study the scientific basis for the effect of branched chain amino acid (BCAA) supplementation in liver cancer patients. Can it improve their recovery in terms of nutritional status and albumin levels, and does it changes the duration of hospital stay, after surgery?Search strategyFive extensive searches were performed on PubMed and Cochrane after appropriate study material.

Aquatic organisms are usually not exposed to single substances but rather to mixtures of toxicants in streams located in agricultural areas. The transport of pesticides used in the agricultural area in Sweden is monitored with continuous environmental supervision every year. During 2002-2008 an average of 10 pesticides were found in each sample and 40% of the samples contained substances with concentrations higher than the Water Quality Standards. Chemical risk management is normally based on single-test evaluations. A problem when assessing mixture toxicities is that the constituents and concentrations of pollutants in the environment vary greatly.

Aquatic organisms are usually not exposed to single substances but rather to mixtures of toxicants in streams located in agricultural areas. The transport of pesticides used in the agricultural area in Sweden is monitored with continuous environmental supervision every year. During 2002-2008 an average of 10 pesticides were found in each sample and 40% of the samples contained substances with concentrations higher than the Water Quality Standards. Chemical risk management is normally based on single-test evaluations. A problem when assessing mixture toxicities is that the constituents and concentrations of pollutants in the environment vary greatly.

Aquatic organisms are usually not exposed to single substances but rather to mixtures of toxicants in streams located in agricultural areas. The transport of pesticides used in the agricultural area in Sweden is monitored with continuous environmental supervision every year. During 2002-2008 an average of 10 pesticides were found in each sample and 40% of the samples contained substances with concentrations higher than the Water Quality Standards. Chemical risk management is normally based on single-test evaluations. A problem when assessing mixture toxicities is that the constituents and concentrations of pollutants in the environment vary greatly.

The main purpose of the project was to identify potential environmentally harmful substances which can be leached from rubber asphalt. A method for analysing asphalt was developed and three rubber asphalt materials were analysed after being cryogrinded. One of the materials was also tested in a road machine made for testing of asphalt paving. The particles created in the machine were analysed in the same manner as the cryogrinded asphalt materials.The asphalt materials were leached by water during 24 hours. The leachates were extracted with dichloromethane, dried with sodium sulphate and concentrated to a small volume.

An analysis of a specific application of anaerobic wastewater treatment at a pulp and board mill, Stora Enso Skoghall, was carried out. A literature study was done and effluent wastewater from CTMP pulp production was analyzed. The analysis consisted of a broad constituent analysis and an anaerobic treatment trial. Results from these test where used to calculate the treatment effectiveness and resulting energy potential at the mill.The literature study and constituent analysis showed that toxicity of the water to be treated, due to wood extractives and sulphur content, was of concern. Detoxification chemicals targeting these constituents where used in the anaerobic treatment trial.

Mykotoxinet fumonisin B1 som förekommer i hela världen på framförallt majs, har visats ge upphov till flera olika toxiska effekter hos en mängd olika djurslag. De mest specifika är leukoencefalomalaci hos häst (ELEM) och lungödem hos gris (PPE), men även skador i lever, njurar och hjärt-kärlsystemet samt carcinogenicitet har observerats. Effekterna skiljer sig en hel del mellan olika djurslag, vilket den här uppsatsen syftade att hitta möjliga anledningar till. Dessutom var syftet att sammanställa information om fumonisins verkningsmekanismer ? både bekräftade och mer osäkra sådana, samt beskriva de toxiska effekterna hos olika djur och i olika organ och även ta upp diagnosticering, vilken dos som krävs för att orsaka sjukdom samt jämföra de rekommenderade gränsvärden som har satts upp för fumonisiner i foder med forskningsresultat.

There is convincing research which shows that the enzyme alkaline phosphatase (ALP) has a central role in the mineralization of bone, more precisely that its catalytic activity is needed in the process. ALP is found on the surface of matrix vesicles where the mineral is formed. One theory about the function of the enzyme is that it binds to fibrous collagen in the bone and thereby incorporating the mineral into the bone. The purpose of this study is to establish whether ALP binds to collagen. If this is the case, more elaborate studies around this will be performed.

Mussel meal is a potential source of protein, with a good composition of amino acids, for laying hens and broiler chickens, and may replace the use of fish meal in organic poultry production. Lead and cadmium are heavy metals which occur in the environment and can be accumulated in mussels. When poultry are exposed to heavy metals, the metals are absorbed in the small intestine and distributed in the body in the form of ions, complexes or bound to proteins. In poultry, lead accumulates in bone tissue, liver and kidneys, while cadmium accumulates in liver and kidneys. Generally very low concentrations of these heavy metals occur in muscles of broilers which have been exposed to feed contaminated with cadmium or lead.

Since several lifestyle diseases are associated with obesity much research is carried out within the area. Researchers have found that oxidation of fatty acids within the body?s cells may give rise to peripheral signals which regulate food intake, but it is still unclear where such a mechanism takes place. Although much evidence suggests that it is the hepatocytes in the liver that send signals regulating food intake, some researchers have begun to question this theory. Instead they argue that the mechanism takes place within the enterocytes since they are well localised in the gut for such assignment.

Bakgrund: Levercirros är ett sjukdomstillstånd som har hög mortalitet om inte en levertransplantation genomförs. Väntelistan till transplantation är lång samtidigt som organbehovet ökar. Syfte: Syftet med studien är att beskriva patientens upplevelser och livskvalitet i väntan på en levertransplantation. Metod: En litteraturöversikt valdes där 9 vetenskapliga artiklar granskades och analyserades enligt Fribergs modell (2006). Resultat: Beskedet om att bli uppsatt på väntelista präglades av både positiva och negativa känslor; glädje, lättnad, oro samt tveksamhet.

Erasteel Kloster AB Söderfors have been commissioned by the county administrative board in Uppsala län to make an inventory of possible contaminations in theirs industrial- and landfill areas on the basis of the Swedish Environmental Protection Agency?s; ?Method of Surveying Contaminated Sites-phase 1? (MIFO-fas 1). The inventory starts with maps and archive studies, place visits and interviews, and finally a risk classification is done. A risk classification is a compilation of four categories; pollutant toxicity, contamination level, possible spreading condition of the pollutant, sensitivity and protection value of the environment. In this paper five partial areas (Holmen- and Jörsöområdet, Järnsvampsområdet, Ingsådeponin, Östra verken and Myrområdet) have been described from a historical point of view. Only parts of four areas have been risk classified (Holmen- and Jörsöområdet, Järnsvampsområdet, Ingsådeponin and Östra verken), due to that the other areas isn?t own by Erasteel Kloster AB. Holmen- and Jörsöområdet Holmen- and Jörsöområdet have during the entire activity time been carried out as the production core in the company.